Southern Illinois University
2021 Football Schedule
Overall8-50.615
Conference5-30.625
StreakL1
Home3-2
Away5-3
Neutral0-0
| Date | Time | At | Opponent | Location | Tournament | Result |
|---|---|---|---|---|---|---|
| Sep 2 (Thu) | 6:30 PM | Away | Southeast Missouri | Cape Girardeau, MO | W 47-21 | |
| Sep 11 (Sat) | 6:00 PM | Away | Kansas St. | Manhattan, KS | L 23-31 | |
| Sep 18 (Sat) | 6:00 PM | Home | Dayton | Carbondale, IL (Saluki Stadium) | W 55-3 | |
| Sep 25 (Sat) | 2:00 PM | Home | Illinois St. | Carbondale, IL (Saluki Stadium) | W 35-17 | |
| Oct 2 (Sat) | 3:00 PM | Away | Western Illinois | Macomb, IL | W 31-30 | |
| Oct 9 (Sat) | 2:00 PM | Away | #2 South Dakota St. | Brookings, SD | W 42-41 | |
| Oct 16 (Sat) | 2:00 PM | Home | #22 North Dakota | Carbondale, IL (Saluki Stadium) | W 31-28 | |
| Oct 30 (Sat) | 4:00 PM | Away | #16 Northern Iowa | Cedar Falls, IA | L 16-23 | |
| Nov 6 (Sat) | 12:00 PM | Home | #17 Missouri St. | Carbondale, IL (Saluki Stadium) | L 28-38 | |
| Nov 13 (Sat) | 12:00 PM | Away | Indiana St. | Terre Haute, IN (Memorial Stadium) | W 47-21 | |
| Nov 20 (Sat) | 12:00 PM | Home | Youngstown St. | Carbondale, IL (Saluki Stadium) | L 18-35 | |
| Nov 27 (Sat) | 5:00 PM | Away | #17 South Dakota | Vermillion, SD | FCS Playoffs | W 22-10 |
| Dec 4 (Sat) | 2:30 PM | Away | #3 North Dakota St. | Fargo, ND | FCS Playoffs | L 7-38 |